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OCR: steroid The metyrapone test, based on the urina e enzyme or ACTH response to this 11p-hydroxyla diagnostic blocker, has now been shown to be of no at forms of value. Abnormal, high molecular- weig with ectopic ACTH ('big ACTH') are frequently seen sources and, in rare instances, when caused by apituitary-dependent Cushing's disease is large tumour. See also: erapy . Cushing's Syndrome - Metyrapone Th